Heat shock protein HSP 90-alpha (Protein name
), HS90A_RAT from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
Hsp90aa1(Hsp86;Hspca);
Protein name:
Heat shock protein HSP 90-alpha;
Alternative:
Heat shock 86 kDa(HSP 86;HSP86);
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems.
Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
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Precision
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Recovery
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Linearity
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References
1.
"Cloning of rat 86-kDa heat shock protein gene and promoter." Li C.W.
,
Chang M.T.
,
Lai Y.
,
Chang W.M.
,
Lai Y.K.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
"Cloning of full length cDNA of rat 86-kDa heat shock protein gene." Lai Y.R.
,
Chang M.D.
,
Chang W.M.
,
Su C.Y.
,
Lai Y.K.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: PROTEIN SEQUENCE OF 154-173; 329-339 AND 347-356;IDENTIFICATION BY MASS SPECTROMETRY